Celastrol Induces Apoptosis in Gefitinib-Resistant Non-Small Cell Lung Cancer Cells via Caspases-Dependent Pathways and Hsp90 Client Protein Degradation

Celastrol Induces Apoptosis in Gefitinib-Resistant Non-Small Cell Lung Cancer Cells via Caspases-Dependent Pathways and Hsp90 Client Protein Degradation

Celastrol, a triterpene extracted from the Chinese herb Tripterygium wilfordii, has been shown to have multiple bioactivities. Although among these activities, its anti-cancer effects have attracted the most attention, the effect of celastrol on gefitinib-resistant non-small cell lung cancer (NSCLC)...

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Bibliographic Details
Main Authors: Xing-Xing Fan, Na Li, Jian-Lin Wu, Yan-Ling Zhou, Jian-Xing He, Liang Liu, Elaine Lai-Han Leung
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Molecules
Subjects:
celastrol
gefitinib resistance
NSCLC
apoptosis
Hsp90
EGFR
Online Access:http://www.mdpi.com/1420-3049/19/3/3508

Internet

http://www.mdpi.com/1420-3049/19/3/3508

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