Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL

Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL

Abstract Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic paradigm of small vessel disease (SVD) caused by NOTCH3 mutations that stereotypically lead to the vascular accumulation of NOTCH3 around smooth muscle cells and pericytes. Whit...

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Bibliographic Details
Main Authors: Rikesh M. Rajani, Julien Ratelade, Valérie Domenga-Denier, Yoshiki Hase, Hannu Kalimo, Raj N. Kalaria, Anne Joutel
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Acta Neuropathologica Communications
Subjects:
CADASIL
Small vessel disease
Blood brain barrier
White matter lesions
Pericytes
Online Access:http://link.springer.com/article/10.1186/s40478-019-0844-x

Internet

http://link.springer.com/article/10.1186/s40478-019-0844-x

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