Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells.

Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells.

Infection with the helminth Schistosoma (S.) mansoni drives the development of interleukin (IL)-10-producing regulatory B (Breg) cells in mice and man, which have the capacity to reduce experimental allergic airway inflammation and are thus of high therapeutic interest. However, both the involved an...

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Bibliographic Details
Main Authors: Simone Haeberlein, Katja Obieglo, Arifa Ozir-Fazalalikhan, Mathilde A M Chayé, Henrike Veninga, Luciën E P M van der Vlugt, Astrid Voskamp, Louis Boon, Joke M M den Haan, Lotte B Westerhof, Ruud H P Wilbers, Arjen Schots, Gabriele Schramm, Cornelis H Hokke, Hermelijn H Smits
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1006539

Internet

https://doi.org/10.1371/journal.ppat.1006539

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