T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions

T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions

T cells are the most abundant cell type found in afferent lymph, but their migration through lymphatic vessels (LVs) remains poorly understood. Performing intravital microscopy in the murine skin, we imaged T cell migration through afferent LVs in vivo. T cells entered into and actively migrated wit...

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Bibliographic Details
Main Authors: Alvaro Teijeira, Morgan C. Hunter, Erica Russo, Steven T. Proulx, Thomas Frei, Gudrun F. Debes, Marc Coles, Ignacio Melero, Michael Detmar, Ana Rouzaut, Cornelia Halin
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
lymphatic vessels
intravital microscopy
T cell
cell migration
inflammation
ICAM-1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716318009

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http://www.sciencedirect.com/science/article/pii/S2211124716318009

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