Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency.

Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency.

OBJECTIVE:Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. MGP deficiency is associated with medial calcification of the arterial wall, in a process that involves both osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and mes...

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Bibliographic Details
Main Authors: Rajeev Malhotra, Megan F Burke, Trejeeve Martyn, Hannah R Shakartzi, Timothy E Thayer, Caitlin O'Rourke, Pingcheng Li, Matthias Derwall, Ester Spagnolli, Starsha A Kolodziej, Konrad Hoeft, Claire Mayeur, Pawina Jiramongkolchai, Ravindra Kumar, Emmanuel S Buys, Paul B Yu, Kenneth D Bloch, Donald B Bloch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4300181?pdf=render

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http://europepmc.org/articles/PMC4300181?pdf=render

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