Degradation of endocannabinoids in chronic migraine and medication overuse headache

Chronic migraine (CM) is frequently associated with medication overuse headache (MOH). The endocannabinoid system plays a role in modulating pain including headache and is involved in the common neurobiological mechanism underlying drug addiction and reward system. Anandamide (AEA) and 2-arachidonoy...

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Bibliographic Details
Main Authors: L.M. Cupini, C. Costa, P. Sarchielli, M. Bari, N. Battista, P. Eusebi, P. Calabresi, M. Maccarrone
Format: Article
Language:English
Published: Elsevier 2008-05-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000065