Crystal structures, absolute configurations and molecular docking studies of naftopidil enantiomers as α1D-adrenoceptor antagonists

Crystal structures, absolute configurations and molecular docking studies of naftopidil enantiomers as α1D-adrenoceptor antagonists

Chiral drug naftopidil (NAF), a specific α1D-adrenoceptor (AR) antagonist for the treatment of benign prostatic hyperplasia, was used in racemic form for several decades. Our recent work declared that NAF enantiomers showed the same antagonistic effects on the α1D-AR, but the binding mechanism of th...

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Bibliographic Details
Main Authors: Wei Xu, Junjun Huang, Renwang Jiang, Mu Yuan
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Naftopidil
Crystal structure
α1D-Adrenoceptor antago- nists
Binding mode
Pharmacophore model
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383516304634

Internet

http://www.sciencedirect.com/science/article/pii/S2211383516304634

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