DNA Methylation of TGFβ Target Genes: Epigenetic Control of TGFβ Functional Duality in Liver Cancer

Transforming growth factor beta (TGFβ) plays a key role in liver carcinogenesis. However, its action is complex, since TGFβ exhibits tumor-suppressive or oncogenic properties, depending on the tumor stage. At an early stage TGFβ exhibits cytostatic features, but at a later stage it promotes cell gro...

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Bibliographic Details
Main Authors: Kevin Bévant, Matthis Desoteux, Abdel Hady A. Abdel Wahab, Sabrin A. Abdel Wahab, Ayman Mohamed Metwally, Cédric Coulouarn
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
EMT
Online Access:https://www.mdpi.com/2073-4409/10/9/2207