Linking Pesticide Exposure with Pediatric Leukemia: Potential Underlying Mechanisms

Linking Pesticide Exposure with Pediatric Leukemia: Potential Underlying Mechanisms

Leukemia is the most common cancer in children, representing 30% of all childhood cancers. The disease arises from recurrent genetic insults that block differentiation of hematopoietic stem and/or progenitor cells (HSPCs) and drives uncontrolled proliferation and survival of the differentiation-bloc...

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Bibliographic Details
Main Authors: Antonio F. Hernández, Pablo Menéndez
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:International Journal of Molecular Sciences
Subjects:
infant and childhood leukemia
hematopoietic stem/progenitor cells
chromosomal rearrangements
topoisomerase II
pesticides
DNA double-strand break
oxidative stress
Online Access:http://www.mdpi.com/1422-0067/17/4/461

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http://www.mdpi.com/1422-0067/17/4/461

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