Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs
Phthalidyl esters, commonly used prodrug moieties, are mostly prepared as a racemate. Here, the authors report an N-heterocylcic carbene-catalysed enantioselective acetalization of carboxylic acids and dialdehydes to give phthalidyl esters in high yields with good enantioselectivity.
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-04-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-09445-x |