m6A RNA methylation impacts fate choices during skin morphogenesis

m6A RNA methylation impacts fate choices during skin morphogenesis

N6-methyladenosine is the most prominent RNA modification in mammals. Here, we study mouse skin embryogenesis to tackle m6A’s functions and physiological importance. We first landscape the m6A modifications on skin epithelial progenitor mRNAs. Contrasting with in vivo ribosomal profiling, we unearth...

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Bibliographic Details
Main Authors: Linghe Xi, Thomas Carroll, Irina Matos, Ji-Dung Luo, Lisa Polak, H Amalia Pasolli, Samie R Jaffrey, Elaine Fuchs
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
N6-methyladenosine
skin epithelial morphogenesis
lineage specification
miCLIP
RNA metabolism
Online Access:https://elifesciences.org/articles/56980

Internet

https://elifesciences.org/articles/56980

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