Proteomic Analysis of Rhesus Macaque Brain Explants Treated With Borrelia burgdorferi Identifies Host GAP-43 as a Potential Factor Associated With Lyme Neuroborreliosis

Proteomic Analysis of Rhesus Macaque Brain Explants Treated With Borrelia burgdorferi Identifies Host GAP-43 as a Potential Factor Associated With Lyme Neuroborreliosis

BackgroundLyme neuroborreliosis (LNB) is one of the most dangerous manifestations of Lyme disease, but the pathogenesis and inflammatory mechanisms are not fully understood.MethodsCultured explants from the frontal cortex of rhesus monkey brain (n=3) were treated with live Borrelia burgdorferi (Bb)...

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Bibliographic Details
Main Authors: Lianbao Li, Lisha Luo, Taigui Chen, Wenjing Cao, Xin Xu, Yu Zhang, Peng Yue, Yuxin Fan, Jingjing Chen, Meixiao Liu, Mingbiao Ma, Lvyan Tao, Yun Peng, Yan Dong, Bingxue Li, Suyi Luo, Jing Kong, Guozhong Zhou, Shiyuan Wen, Aihua Liu, Fukai Bao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
proteomic analysis
lyme neuroborreliosis
neuroinflammation
HMC3
Borrelia burgdorferi
GAP-43
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.647662/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2021.647662/full

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