Phenotypic adaptations of Leishmania donovani to recurrent miltefosine exposure and impact on sand fly infection

Phenotypic adaptations of Leishmania donovani to recurrent miltefosine exposure and impact on sand fly infection

Abstract Background Since the introduction of miltefosine (MIL) as first-line therapy in the kala-azar elimination programme in the Indian subcontinent, treatment failure rates have been increasing. Since parasite infectivity and virulence may become altered upon treatment relapse, this laboratory s...

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Bibliographic Details
Main Authors: Sarah Hendrickx, Lieselotte Van Bockstal, Dimitri Bulté, Annelies Mondelaers, Hamide Aslan, Luis Rivas, Louis Maes, Guy Caljon
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Parasites & Vectors
Subjects:
Miltefosine
Leishmania
Fitness
Lutzomyia longipalpis
Drug uptake
Online Access:http://link.springer.com/article/10.1186/s13071-020-3972-z

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http://link.springer.com/article/10.1186/s13071-020-3972-z

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