Hepatitis B Virus Pre-S2 Mutant Induces Aerobic Glycolysis through Mammalian Target of Rapamycin Signal Cascade.

Hepatitis B Virus Pre-S2 Mutant Induces Aerobic Glycolysis through Mammalian Target of Rapamycin Signal Cascade.

Hepatitis B virus (HBV) pre-S2 mutant can induce hepatocellular carcinoma (HCC) via the induction of endoplasmic reticulum stress to activate mammalian target of rapamycin (MTOR) signaling. The association of metabolic syndrome with HBV-related HCC raises the possibility that pre-S2 mutant-induced M...

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Bibliographic Details
Main Authors: Chiao-Fang Teng, Wen-Chuan Hsieh, Han-Chieh Wu, Yih-Jyh Lin, Hung-Wen Tsai, Wenya Huang, Ih-Jen Su
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4409318?pdf=render

Internet

http://europepmc.org/articles/PMC4409318?pdf=render

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