A new view of transcriptome complexity and regulation through the lens of local splicing variations

A new view of transcriptome complexity and regulation through the lens of local splicing variations

Alternative splicing (AS) can critically affect gene function and disease, yet mapping splicing variations remains a challenge. Here, we propose a new approach to define and quantify mRNA splicing in units of local splicing variations (LSVs). LSVs capture previously defined types of alternative spli...

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Bibliographic Details
Main Authors: Jorge Vaquero-Garcia, Alejandro Barrera, Matthew R Gazzara, Juan González-Vallinas, Nicholas F Lahens, John B Hogenesch, Kristen W Lynch, Yoseph Barash
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-02-01
Series:eLife
Subjects:
alternative splicing
transcriptomic
alzheimer's disease
camk2
ptb1
statistical modeling
Online Access:https://elifesciences.org/articles/11752

Internet

https://elifesciences.org/articles/11752

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