UGT1A1 polymorphism has a prognostic effect in patients with stage IB or II uterine cervical cancer and one or no metastatic pelvic nodes receiving irinotecan chemotherapy: a retrospective study

UGT1A1 polymorphism has a prognostic effect in patients with stage IB or II uterine cervical cancer and one or no metastatic pelvic nodes receiving irinotecan chemotherapy: a retrospective study

Abstract Background Uridine diphosphate glucuronosyltransferase 1 family polypeptide A1 (UGT1A1) is a predictive biomarker for the side-effects of irinotecan chemotherapy, which reduces the volume of tumors harboring UGT1A1 polymorphisms. We aimed to determine whether UGT1A1 polymorphisms can predic...

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Bibliographic Details
Main Authors: Hideki Matsuoka, Ryusuke Murakami, Kaoru Abiko, Ken Yamaguchi, Akihito Horie, Junzo Hamanishi, Tsukasa Baba, Masaki Mandai
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Cancer
Subjects:
Irinotecan chemotherapy
Uterine cervical cancer
UGT1A1 polymorphisms
Online Access:http://link.springer.com/article/10.1186/s12885-020-07225-1

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http://link.springer.com/article/10.1186/s12885-020-07225-1

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