Infection by the Protozoan Parasite Toxoplasma gondii Inhibits Host MNK1/2-eIF4E Axis to Promote Its Survival

Infection by the Protozoan Parasite Toxoplasma gondii Inhibits Host MNK1/2-eIF4E Axis to Promote Its Survival

The obligate intracellular parasite Toxoplasma gondii reprograms host gene expression through multiple mechanisms that promote infection, including the up-regulation of mTOR-dependent host mRNA translation. In addition to the mTOR-4E-BP1/2 axis, MAPK-interacting kinases 1 and 2 (MNK1/2) control the...

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Bibliographic Details
Main Authors: Louis-Philippe Leroux, Visnu Chaparro, Maritza Jaramillo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Toxoplasma gondii
MNK1/2
eIF4E phosphorylation
p38 MAPK
macrophages
IFNγ
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00488/full

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https://www.frontiersin.org/article/10.3389/fcimb.2020.00488/full

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