Unbalanced Metalloproteinase-9 and Tissue inhibitors of Metalloproteinases Ratio Predicts Hemorrhagic Transformation of Lesion in Ischemic Stroke Patients Treated with Thrombolysis: Results from the MAGIC Study

Unbalanced Metalloproteinase-9 and Tissue inhibitors of Metalloproteinases Ratio Predicts Hemorrhagic Transformation of Lesion in Ischemic Stroke Patients Treated with Thrombolysis: Results from the MAGIC Study

Background Experimentally, metalloproteinases (MMPs) play a detrimental role related to severity of ischemic brain lesions. Both MMPs activity and function in tissues reflect the balance between MMPs and tissue inhibitors of metalloproteinases (TIMPs). We aimed to evaluate the role of MMPs/TIMPs bal...

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Main Authors: Benedetta ePiccardi, Vanessa ePalumbo, Mascia eNesi, Patrizia eNencini, Anna Maria eGori, Betti eGiusti, Giovanni ePracucci, Paolina eTonelli, Eleonora eInnocenti, Alice eSereni, Elena eSticchi, Danilo eToni, Paolo eBovi, Mario eGuidotti, Maria Rosaria eTola, Domenico eConsoli, Giuseppe eMicieli, Rossana eTassi, Giovanni eOrlandi, Francesco ePerini, Norina eMarcello, Antonia eNucera, Francesca eMassaro, DeLodovici eMaria Luisa, Maria eSessa, Rosanna eAbbate, Domenico eInzitari
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Neurology
Subjects:
Stroke
Thrombolytic Therapy
Tissue Inhibitor of Metalloproteinases
death
Stroke subtypes
Metalloproteinases
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00121/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00121/full

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