Pharmacokinetic Modeling of Morphine’s Effect on Plasma Concentrations of Ticagrelor and Its Metabolite in Healthy Volunteers

Pharmacokinetic Modeling of Morphine’s Effect on Plasma Concentrations of Ticagrelor and Its Metabolite in Healthy Volunteers

This study aimed to build a mathematical model describing the pharmacokinetics of ticagrelor and its active metabolite (AR-C124910XX) in a stable setting with concomitant administration of morphine. The model consists of a set of four differential equations prepared upon the available knowledge rega...

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Bibliographic Details
Main Authors: Katarzyna Buszko, Krystian Kubica, Eva-Luise Hobl, Piotr Adamski, Kacper Wnuk, Bernd Jilma, Jacek Kubica
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Physiology
Subjects:
modeling of pharmacokinetics
morphine
ticagrelor
AR-C124910XX
morphine’s effect
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.663170/full

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https://www.frontiersin.org/articles/10.3389/fphys.2021.663170/full

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