Fucoidan from Fucus vesiculosus attenuates doxorubicin-induced acute cardiotoxicity by regulating JAK2/STAT3-mediated apoptosis and autophagy

Fucoidan from Fucus vesiculosus attenuates doxorubicin-induced acute cardiotoxicity by regulating JAK2/STAT3-mediated apoptosis and autophagy

Doxorubicin (DOX) is well-known for its potent antitumor activity but limited by its multiple and serious adverse effects. A major adverse effect is acute cardiotoxicity; yet, its mechanism has not been elucidated. Fucoidan is a multifunctional and nontoxic polysaccharide that is widely studied beca...

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Bibliographic Details
Main Authors: Jie Zhang, Zhenzhu Sun, Na Lin, Wenqiang Lu, Xingxiao Huang, Jingfan Weng, Shimin Sun, Chuanjing Zhang, Qi Yang, Guozhong Zhou, Hangyuan Guo, Jufang Chi
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Fucoidan
Doxorubicin
Cardiotoxicity
Apoptosis and autophagy
JAK2/STAT3 pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220307277

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http://www.sciencedirect.com/science/article/pii/S0753332220307277

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