Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members

Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members

Anti-apoptotic B cell lymphoma 2 (BCL2) family members (BCL2, MCL1, BCLxL, BCLW, and BFL1) are key players in the regulation of intrinsic apoptosis. Dysregulation of these proteins not only impairs normal development, but also contributes to tumor progression and resistance to various anti-cancer th...

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Bibliographic Details
Main Authors: Jia Cui, William J. Placzek
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:International Journal of Molecular Sciences
Subjects:
anti-apoptotic BCL2 subfamily
apoptosis
post-transcriptional regulation
RNA binding proteins
microRNA
alternative splicing
mRNA stability
mRNA subcellular localization
Online Access:http://www.mdpi.com/1422-0067/19/1/308

Internet

http://www.mdpi.com/1422-0067/19/1/308

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