Kinetic Model for Signal Binding to the Quorum Sensing Regulator LasR

Kinetic Model for Signal Binding to the Quorum Sensing Regulator LasR

We propose a kinetic model for the activation of the las regulon in the opportunistic pathogen Pseudomonas aeruginosa. The model is based on in vitro data and accounts for the LasR dimerization and consecutive activation by binding of two OdDHL signal molecules. Experimentally, the production of the...

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Bibliographic Details
Main Authors: Jesper Ferkinghoff-Borg, Thomas Sams, Michael Givskov, Martin Welch, Tim Holm Jakobsen, Thomas Bjarnsholt, Anetta Claussen
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:International Journal of Molecular Sciences
Subjects:
quorum sensing
LasR
Pseudomonas aeruginosa
OdDHL
C12-HSL
signal molecule
ligand
Online Access:http://www.mdpi.com/1422-0067/14/7/13360

Internet

http://www.mdpi.com/1422-0067/14/7/13360

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