ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

Angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2 have been implicated in cell entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). The expression of ACE2 and TMPRSS2 in the lung epithelium might have...

Full description

Bibliographic Details
Main Authors: Dipender Gill, Marios Arvanitis, Paul Carter, Ana I. Hernández Cordero, Brian Jo, Ville Karhunen, Susanna C. Larsson, Xuan Li, Sam M. Lockhart, Amy Mason, Evanthia Pashos, Ashis Saha, Vanessa Y. Tan, Verena Zuber, Yohan Bossé, Sarah Fahle, Ke Hao, Tao Jiang, Philippe Joubert, Alan C. Lunt, Willem Hendrik Ouwehand, David J. Roberts, Wim Timens, Maarten van den Berge, Nicholas A. Watkins, Alexis Battle, Adam S. Butterworth, John Danesh, Emanuele Di Angelantonio, Barbara E. Engelhardt, James E. Peters, Don D. Sin, Stephen Burgess
Format: Article
Language:English
Published: The Royal Society 2020-11-01
Series:Royal Society Open Science
Subjects:
covid-19
mendelian randomization
angiotensin-converting enzyme inhibitors
genetic epidemiology
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.200958

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.200958

Similar Items