Internalization, Intracellular Trafficking, Biodistribution of Monoclonal Antibody 806: A Novel Anti-Epidermal Growth Factor Receptor Antibody

Overexpression of the epidermal growth factor receptor (EGFR) in epithelial tumors is associated with poor prognosis and is the target for a number of cancer therapeutics. Monoclonal antibody (mAb) 806 is a novel anti-EGFR antibody with significant therapeutic efficacy in tumor models when used as...

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Bibliographic Details
Main Authors: Rushika M. Perera, Roberto Zoncu, Terrance G. Johns, Marc Pypaert, Fook-Thean Lee, Ira Mellman, Lloyd J. Old, Derek K. Toomre, Andrew M. Scott
Format: Article
Language:English
Published: Elsevier 2007-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607801205