Chronic Fluoxetine Impairs the Effects of 5-HT1A and 5-HT2C Receptors Activation in the PAG and Amygdala on Antinociception Induced by Aversive Situation in Mice

Chronic Fluoxetine Impairs the Effects of 5-HT1A and 5-HT2C Receptors Activation in the PAG and Amygdala on Antinociception Induced by Aversive Situation in Mice

Growing evidence suggests an important role of fluoxetine with serotonin 5-HT1A and 5-HT2C receptors in the modulation of emotion and nociception in brain areas such as the amygdala and periaqueductal gray (PAG). Acute fluoxetine impairs 5-HT2C (but not 5-HT1A) receptor activation in the amygdaloid...

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Bibliographic Details
Main Authors: Daniela Baptista-de-Souza, Lígia Renata Rodrigues Tavares, Elke Mayumi Furuya-da-Cunha, Paulo Eduardo Carneiro de Oliveira, Lucas Canto-de-Souza, Ricardo Luiz Nunes-de-Souza, Azair Canto-de-Souza
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
fluoxetine
5-HT1A and 5HT2C receptors
serotonin
amygdala
periaqueductal gray matter
antinociception
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00260/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00260/full

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