Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-β Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion

Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-β Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion

Degeneration of basal forebrain cholinergic neurons (BFCNs) precedes hippocampal degeneration and pathological amyloid-beta (Aβ) accumulation, and underpins the development of cognitive dysfunction in sporadic Alzheimer’s disease (AD). We hypothesized that degeneration of BFCNs causes a decrease in...

Full description

Bibliographic Details
Main Authors: Marion T. Turnbull, Zoran Boskovic, Elizabeth J. Coulson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Alzheimer’s disease
basal forebrain
cholinergic neuron
amyloid-β
brain-derived neurotrophic factor
APP/PS1 transgenic mouse
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00051/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00051/full

Similar Items