Deleterious c-Cbl Exon Skipping Contributes to Human Glioma

Deleterious c-Cbl Exon Skipping Contributes to Human Glioma

c-Cbl, a RING-type ubiquitin E3 ligase, downregulates various receptor tyrosine kinases (e.g., epidermal growth factor receptor (EGFR)), leading to inhibition of cell proliferation. Moreover, patients with myeloid neoplasm frequently harbor c-Cbl mutations, implicating the role of c-Cbl as a tumor s...

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Bibliographic Details
Main Authors: Min Woo Seong, Seung Hyeun Ka, Ji Ho Park, Jong Ho Park, Hee Min Yoo, Seung Wook Yang, Jung Mi Park, Dongeun Park, Soon Tae Lee, Jae Hong Seol, Chin Ha Chung
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S147655861500072X

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http://www.sciencedirect.com/science/article/pii/S147655861500072X

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