Intrathecally Administered Apelin-13 Alleviated Complete Freund’s Adjuvant-Induced Inflammatory Pain in Mice

Intrathecally Administered Apelin-13 Alleviated Complete Freund’s Adjuvant-Induced Inflammatory Pain in Mice

Apelin is the endogenous ligand for APJ, a G-protein-coupled receptor. Apelin gene and protein are widely distributed in the central nervous system and peripheral tissues. The role of apelin in chronic inflammatory pain is still unclear. In the present study, a mouse model of complete Freund’s adjuv...

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Bibliographic Details
Main Authors: Shuangyu Lv, Xiaomei Zhang, Yuchen Zhou, Yu Feng, Yanjie Yang, Xinchun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
apelin
inflammatory pain
NMDA receptor
spinal cord
Fos
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01335/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01335/full

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