Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA.

Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA.

The purpose of the present study was to investigate whether cilostazol, a phosphodiesterase-III inhibitor and antiplatelet drug, would prevent tPA-associated hemorrhagic transformation. Mice subjected to 6-h middle cerebral artery occlusion were treated with delayed tPA alone at 6 h, with combined t...

Full description

Bibliographic Details
Main Authors: Mitsunori Ishiguro, Keisuke Mishiro, Yasuyuki Fujiwara, Huayue Chen, Hiroshi Izuta, Kazuhiro Tsuruma, Masamitsu Shimazawa, Shinichi Yoshimura, Masahiko Satoh, Toru Iwama, Hideaki Hara
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21151895/pdf/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21151895/pdf/?tool=EBI

Similar Items