Ligand-mediated Endocytosis and Trafficking of the Insulin-like Growth Factor Receptor I and Insulin Receptor Modulate Receptor Function

Ligand-mediated Endocytosis and Trafficking of the Insulin-like Growth Factor Receptor I and Insulin Receptor Modulate Receptor Function

The insulin-like growth factor (IGF-I) system and its two major receptors, the IGF-IR and IR, plays a central role in a variety of physiological cellular processes including growth, differentiation, motility and glucose homeostasis. The IGF-IR is also essential for tumorigenesis through its capacity...

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Bibliographic Details
Main Authors: Alaide eMorcavallo, Manuela eStefanello, Renato V Iozzo, Antonino eBelfiore, Andrea eMorrione
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Endocrinology
Subjects:
Endocytosis
signaling
trafficking
IR
IGF-IR
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00220/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00220/full

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