Genomic and secondary metabolite analyses of Streptomyces sp. 2AW provide insight into the evolution of the cycloheximide pathway

Genomic and secondary metabolite analyses of Streptomyces sp. 2AW provide insight into the evolution of the cycloheximide pathway

The dearth of new antibiotics in the face of widespread antimicrobial resistance makes developing innovative strategies for discovering new antibiotics critical for the future management of infectious disease. Understanding the genetics and evolution of antibiotic producers will help guide the disco...

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Bibliographic Details
Main Authors: Elizabeth eStulberg, Gabriel Leonardo Lozano, Jesse B Morin, Hyunjun ePark, Ezra G Baraban, Christine eMlot, Christopher eHeffelfinger, Gillian M Phillips, Jason S Rush, Andrew J Phillips, Nichole A Broderick, Michael G Thomas, Eric Vincent Stabb, Jo eHandelsman
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Microbiology
Subjects:
Cycloheximide
bioinformatics
Natural product biosynthesis
glutaramide antibiotics
neutramycin
hygromycin A
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00573/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00573/full

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