Network-based in silico drug efficacy screening

Attempts to predict novel use for existing drugs rarely consider information on the impact on the genes perturbed in a given disease. Here, the authors present a novel network-based drug-disease proximity measure that provides insight on gene specific therapeutic effect of drugs and may facilitate d...

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Bibliographic Details
Main Authors: Emre Guney, Jörg Menche, Marc Vidal, Albert-László Barábasi
Format: Article
Language:English
Published: Nature Publishing Group 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10331