Human transbodies to HCV NS3/4A protease inhibit viral replication and restore host innate immunity

Human transbodies to HCV NS3/4A protease inhibit viral replication and restore host innate immunity

A safe and effective direct acting anti-hepatitis C virus (HCV) agent is still needed. In this study, human single-chain variable fragments of antibody (scFvs) that bound to HCV NS3/4A protein were produced by phage display technology. The engineered scFvs were linked to nonaarginines (R9) for makin...

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Bibliographic Details
Main Authors: Surasak Jittavisutthikul, Watee Seesuay, Jeeraphong Thanongsaksrkul, Kanyarat Thueng-in, Potjanee Srimanote, Rolf G. Werner, Wanpen Chaicumpa
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Immunology
Subjects:
qPCR
innate immunity
phage display
hepatitis C virus (HCV)
NS3/4A protease
Single chain antibody (ScFv)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00318/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00318/full

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