RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
Proper ovarian differentiation requires RUNX1. Here, the authors show that double knockout of Runx1/Foxl2 results in masculinization of fetal ovaries, and that RUNX1 and FOXL2 jointly occupy common chromatin regions to maintain pre-granulosa cell identity in the fetal ovary.
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-11-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-13060-1 |