RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

Proper ovarian differentiation requires RUNX1. Here, the authors show that double knockout of Runx1/Foxl2 results in masculinization of fetal ovaries, and that RUNX1 and FOXL2 jointly occupy common chromatin regions to maintain pre-granulosa cell identity in the fetal ovary.

Bibliographic Details
Main Authors: Barbara Nicol, Sara A. Grimm, Frédéric Chalmel, Estelle Lecluze, Maëlle Pannetier, Eric Pailhoux, Elodie Dupin-De-Beyssat, Yann Guiguen, Blanche Capel, Humphrey H.-C. Yao
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13060-1
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spelling doaj-70611c2bdf5d4776a09548dc9ccd82402021-05-11T11:35:04ZengNature Publishing GroupNature Communications2041-17232019-11-0110111410.1038/s41467-019-13060-1RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2Barbara Nicol0Sara A. Grimm1Frédéric Chalmel2Estelle Lecluze3Maëlle Pannetier4Eric Pailhoux5Elodie Dupin-De-Beyssat6Yann Guiguen7Blanche Capel8Humphrey H.-C. Yao9Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health SciencesIntegrative Bioinformatics Support Group, National Institute of Environmental Health SciencesUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S1085Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S1085UMR BDR, INRA, ENVA, Université Paris SaclayUMR BDR, INRA, ENVA, Université Paris SaclayINRA, UR1037 Fish Physiology and GenomicsINRA, UR1037 Fish Physiology and GenomicsDepartment of Cell Biology, Duke University Medical CenterReproductive and Developmental Biology Laboratory, National Institute of Environmental Health SciencesProper ovarian differentiation requires RUNX1. Here, the authors show that double knockout of Runx1/Foxl2 results in masculinization of fetal ovaries, and that RUNX1 and FOXL2 jointly occupy common chromatin regions to maintain pre-granulosa cell identity in the fetal ovary.https://doi.org/10.1038/s41467-019-13060-1
collection DOAJ
language English
format Article
sources DOAJ
author Barbara Nicol
Sara A. Grimm
Frédéric Chalmel
Estelle Lecluze
Maëlle Pannetier
Eric Pailhoux
Elodie Dupin-De-Beyssat
Yann Guiguen
Blanche Capel
Humphrey H.-C. Yao
spellingShingle Barbara Nicol
Sara A. Grimm
Frédéric Chalmel
Estelle Lecluze
Maëlle Pannetier
Eric Pailhoux
Elodie Dupin-De-Beyssat
Yann Guiguen
Blanche Capel
Humphrey H.-C. Yao
RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
Nature Communications
author_facet Barbara Nicol
Sara A. Grimm
Frédéric Chalmel
Estelle Lecluze
Maëlle Pannetier
Eric Pailhoux
Elodie Dupin-De-Beyssat
Yann Guiguen
Blanche Capel
Humphrey H.-C. Yao
author_sort Barbara Nicol
title RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
title_short RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
title_full RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
title_fullStr RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
title_full_unstemmed RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
title_sort runx1 maintains the identity of the fetal ovary through an interplay with foxl2
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-11-01
description Proper ovarian differentiation requires RUNX1. Here, the authors show that double knockout of Runx1/Foxl2 results in masculinization of fetal ovaries, and that RUNX1 and FOXL2 jointly occupy common chromatin regions to maintain pre-granulosa cell identity in the fetal ovary.
url https://doi.org/10.1038/s41467-019-13060-1
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