MDM2 antagonists boost antitumor effect of androgen withdrawal: implications for therapy of prostate cancer

<p>Abstract</p> <p>Background</p> <p>Hormone therapy is the standard of care for newly diagnosed or recurrent prostate cancers. It uses anti-androgen agents, castration, or both to eliminate cancer promoting effect of testicular androgen. The p53 tumor suppressor contro...

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Bibliographic Details
Main Authors: Packman Kathryn, Xia Mingxuan, Kolinsky Kenneth, Higgins Brian, Tovar Christian, Heimbrook David C, Vassilev Lyubomir T
Format: Article
Language:English
Published: BMC 2011-05-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/10/1/49