Relationship between diffusion capacity and small airway abnormality in COPDGene

Relationship between diffusion capacity and small airway abnormality in COPDGene

Abstract Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD, functional SAD (fSAD) defined by co...

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Bibliographic Details
Main Authors: Rachel N. Criner, Charles R. Hatt, Craig J. Galbán, Ella A. Kazerooni, David A. Lynch, Meredith C. McCormack, Richard Casaburi, Neil R. MacIntyre, Barry J. Make, Fernando J. Martinez, Wassim W. Labaki, Jeffrey L. Curtis, Mei Lan K. Han
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Respiratory Research
Subjects:
Diffusing capacity of the lung (DLCO)
Small airways disease (SAD)
Chronic obstructive pulmonary disease (COPD)
Parametric response mapping (PRM)
Online Access:https://doi.org/10.1186/s12931-019-1237-1

Internet

https://doi.org/10.1186/s12931-019-1237-1

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