Zika virus-based immunotherapy enhances long-term survival of rodents with brain tumors through upregulation of memory T-cells.

Zika virus-based immunotherapy enhances long-term survival of rodents with brain tumors through upregulation of memory T-cells.

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Zika virus (ZIKV) exhibits a tropism for brain tumor cells and has been used as an oncolytic virus to target brain tumors in mice with modest effects on extending median survival. Recent studies have highlighted the potential for combining virotherapy and immunotherapy to target cancer. We postulate...

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Bibliographic Details
Main Authors: Andrew T Crane, Matthew R Chrostek, Venkatramana D Krishna, Maple Shiao, Nikolas G Toman, Clairice M Pearce, Sarah K Tran, Christopher J Sipe, Winston Guo, Joseph P Voth, Shivanshi Vaid, Hui Xie, Wei-Cheng Lu, Will Swanson, Andrew W Grande, Mark R Schleiss, Craig J Bierle, Maxim C-J Cheeran, Walter C Low
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0232858

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https://doi.org/10.1371/journal.pone.0232858

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