Zika virus-based immunotherapy enhances long-term survival of rodents with brain tumors through upregulation of memory T-cells.
Zika virus (ZIKV) exhibits a tropism for brain tumor cells and has been used as an oncolytic virus to target brain tumors in mice with modest effects on extending median survival. Recent studies have highlighted the potential for combining virotherapy and immunotherapy to target cancer. We postulate...
Main Authors: | Andrew T Crane, Matthew R Chrostek, Venkatramana D Krishna, Maple Shiao, Nikolas G Toman, Clairice M Pearce, Sarah K Tran, Christopher J Sipe, Winston Guo, Joseph P Voth, Shivanshi Vaid, Hui Xie, Wei-Cheng Lu, Will Swanson, Andrew W Grande, Mark R Schleiss, Craig J Bierle, Maxim C-J Cheeran, Walter C Low |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0232858 |
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