Study of Validity of PC-3 Derived Xenograft Tumor Model in Athymic Nude Mice for Targeting Therapy of Androgen Receptors in Preclinical Studies of Prostate Cancer

Study of Validity of PC-3 Derived Xenograft Tumor Model in Athymic Nude Mice for Targeting Therapy of Androgen Receptors in Preclinical Studies of Prostate Cancer

Background: Androgen receptors (AR) play an important role in proliferation of cancerous prostatic cells and prevention of apoptotic signaling. Current drugs cannot inhibit the activity of these receptors very well. Establishment of appropriate animal models is essential for discovery of new drugs...

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Bibliographic Details
Main Authors: Samad Muhammadnejad, Ahad Muhammadnejad, Zohreh Mazaheri, Farrokh Tirgari, Mohammad-Ali Oghabian, Maryam Kazem haghighi, Saeid Amanpour
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2016-10-01
Series:Basic & Clinical Cancer Research
Subjects:
Androgen receptor
prostate cancer
xenograft model
Athymic nude mice
Online Access:https://bccr.tums.ac.ir/index.php/bccrj/article/view/19

Internet

https://bccr.tums.ac.ir/index.php/bccrj/article/view/19

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