Study of Validity of PC-3 Derived Xenograft Tumor Model in Athymic Nude Mice for Targeting Therapy of Androgen Receptors in Preclinical Studies of Prostate Cancer

Study of Validity of PC-3 Derived Xenograft Tumor Model in Athymic Nude Mice for Targeting Therapy of Androgen Receptors in Preclinical Studies of Prostate Cancer

Background: Androgen receptors (AR) play an important role in proliferation of cancerous prostatic cells and prevention of apoptotic signaling. Current drugs cannot inhibit the activity of these receptors very well. Establishment of appropriate animal models is essential for discovery of new drugs...

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Main Authors: Samad Muhammadnejad, Ahad Muhammadnejad, Zohreh Mazaheri, Farrokh Tirgari, Mohammad-Ali Oghabian, Maryam Kazem haghighi, Saeid Amanpour
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2016-10-01
Series:Basic & Clinical Cancer Research
Subjects:
Androgen receptor
prostate cancer
xenograft model
Athymic nude mice
Online Access:https://bccr.tums.ac.ir/index.php/bccrj/article/view/19
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spelling doaj-70732cfd3a5f4470b2c1f15863dcc3af2021-04-04T07:07:05ZengTehran University of Medical SciencesBasic & Clinical Cancer Research2228-65272228-54662016-10-0132Study of Validity of PC-3 Derived Xenograft Tumor Model in Athymic Nude Mice for Targeting Therapy of Androgen Receptors in Preclinical Studies of Prostate CancerSamad Muhammadnejad0Ahad Muhammadnejad1Zohreh Mazaheri2Farrokh Tirgari3Mohammad-Ali Oghabian4Maryam Kazem haghighi5Saeid Amanpour6Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, IranCancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, IranVali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, IranCancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, IranResearch Center for Sciences and Technology in Medicine, Tehran University of Medical Sciences Tehran, IranCancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, IranCancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran, AND Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran Background: Androgen receptors (AR) play an important role in proliferation of cancerous prostatic cells and prevention of apoptotic signaling. Current drugs cannot inhibit the activity of these receptors very well. Establishment of appropriate animal models is essential for discovery of new drugs of target therapy in hormone dependent prostate cancer. Materials and Methods: Standard prostatic cancer cell line (PC-3) was injected heterotopically into 9 nude mice. After tumor formation they were excised and sent for histopathologic and AR expression studies by immunohistochemistry. Results: Histological characteristics of prostate cancer were confirmed. Androgen receptors had been expressed in 65 ± 25% of the xenograft tumor cells. Conclusions: This xenograft model is suitable for pharmacological and molecular studies of androgen dependent prostate cancer. https://bccr.tums.ac.ir/index.php/bccrj/article/view/19Androgen receptorprostate cancerxenograft modelAthymic nude mice
collection DOAJ
language English
format Article
sources DOAJ
author Samad Muhammadnejad
Ahad Muhammadnejad
Zohreh Mazaheri
Farrokh Tirgari
Mohammad-Ali Oghabian
Maryam Kazem haghighi
Saeid Amanpour
spellingShingle Samad Muhammadnejad
Ahad Muhammadnejad
Zohreh Mazaheri
Farrokh Tirgari
Mohammad-Ali Oghabian
Maryam Kazem haghighi
Saeid Amanpour
Study of Validity of PC-3 Derived Xenograft Tumor Model in Athymic Nude Mice for Targeting Therapy of Androgen Receptors in Preclinical Studies of Prostate Cancer
Basic & Clinical Cancer Research
Androgen receptor
prostate cancer
xenograft model
Athymic nude mice
author_facet Samad Muhammadnejad
Ahad Muhammadnejad
Zohreh Mazaheri
Farrokh Tirgari
Mohammad-Ali Oghabian
Maryam Kazem haghighi
Saeid Amanpour
author_sort Samad Muhammadnejad
title Study of Validity of PC-3 Derived Xenograft Tumor Model in Athymic Nude Mice for Targeting Therapy of Androgen Receptors in Preclinical Studies of Prostate Cancer
title_short Study of Validity of PC-3 Derived Xenograft Tumor Model in Athymic Nude Mice for Targeting Therapy of Androgen Receptors in Preclinical Studies of Prostate Cancer
title_full Study of Validity of PC-3 Derived Xenograft Tumor Model in Athymic Nude Mice for Targeting Therapy of Androgen Receptors in Preclinical Studies of Prostate Cancer
title_fullStr Study of Validity of PC-3 Derived Xenograft Tumor Model in Athymic Nude Mice for Targeting Therapy of Androgen Receptors in Preclinical Studies of Prostate Cancer
title_full_unstemmed Study of Validity of PC-3 Derived Xenograft Tumor Model in Athymic Nude Mice for Targeting Therapy of Androgen Receptors in Preclinical Studies of Prostate Cancer
title_sort study of validity of pc-3 derived xenograft tumor model in athymic nude mice for targeting therapy of androgen receptors in preclinical studies of prostate cancer
publisher Tehran University of Medical Sciences
series Basic & Clinical Cancer Research
issn 2228-6527
2228-5466
publishDate 2016-10-01
description Background: Androgen receptors (AR) play an important role in proliferation of cancerous prostatic cells and prevention of apoptotic signaling. Current drugs cannot inhibit the activity of these receptors very well. Establishment of appropriate animal models is essential for discovery of new drugs of target therapy in hormone dependent prostate cancer. Materials and Methods: Standard prostatic cancer cell line (PC-3) was injected heterotopically into 9 nude mice. After tumor formation they were excised and sent for histopathologic and AR expression studies by immunohistochemistry. Results: Histological characteristics of prostate cancer were confirmed. Androgen receptors had been expressed in 65 ± 25% of the xenograft tumor cells. Conclusions: This xenograft model is suitable for pharmacological and molecular studies of androgen dependent prostate cancer.
topic Androgen receptor
prostate cancer
xenograft model
Athymic nude mice
url https://bccr.tums.ac.ir/index.php/bccrj/article/view/19
work_keys_str_mv AT samadmuhammadnejad studyofvalidityofpc3derivedxenografttumormodelinathymicnudemicefortargetingtherapyofandrogenreceptorsinpreclinicalstudiesofprostatecancer
AT ahadmuhammadnejad studyofvalidityofpc3derivedxenografttumormodelinathymicnudemicefortargetingtherapyofandrogenreceptorsinpreclinicalstudiesofprostatecancer
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