Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formation.

Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formation.

Nipah virus targets human endothelial cells via NiV-F and NiV-G envelope glycoproteins, resulting in endothelial syncytia formation and vascular compromise. Endothelial cells respond to viral infection by releasing innate immune effectors, including galectins, which are secreted proteins that bind t...

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Bibliographic Details
Main Authors: Omai B Garner, Hector C Aguilar, Jennifer A Fulcher, Ernest L Levroney, Rebecca Harrison, Lacey Wright, Lindsey R Robinson, Vanessa Aspericueta, Maria Panico, Stuart M Haslam, Howard R Morris, Anne Dell, Benhur Lee, Linda G Baum
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2904771?pdf=render

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http://europepmc.org/articles/PMC2904771?pdf=render

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