Transcriptome and IgH Repertoire Analyses Show That CD11chi B Cells Are a Distinct Population With Similarity to B Cells Arising in Autoimmunity and Infection

Transcriptome and IgH Repertoire Analyses Show That CD11chi B Cells Are a Distinct Population With Similarity to B Cells Arising in Autoimmunity and Infection

A distinct B cell population marked by elevated CD11c expression is found in patients with systemic lupus erythematosus (SLE). Cells with a similar phenotype have been described during chronic infection, but variable gating strategies and nomenclature have led to uncertainty of their relationship to...

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Bibliographic Details
Main Authors: Robert W. Maul, Michelle D. Catalina, Varsha Kumar, Prathyusha Bachali, Amrie C. Grammer, Shu Wang, William Yang, Sarfaraz Hasni, Rachel Ettinger, Peter E. Lipsky, Patricia J. Gearhart
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
CD11c
B cells
SLE
autoimmunity
IGH repertoire
B cell transcriptome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.649458/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.649458/full

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