Design and Synthesis of a Series of Truncated Neplanocin Fleximers

Design and Synthesis of a Series of Truncated Neplanocin Fleximers

In an effort to study the effects of flexibility on enzyme recognition and activity, we have developed several different series of flexible nucleoside analogues in which the purine base is split into its respective imidazole and pyrimidine components. The focus of this particular study was to synthe...

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Bibliographic Details
Main Authors: Sarah C. Zimmermann, Elizaveta O'Neill, Godwin U. Ebiloma, Lynsey J. M. Wallace, Harry P. De Koning, Katherine L. Seley-Radtke
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:Molecules
Subjects:
fleximer
carbocyclic nucleosides
3-deazaneplanocin A
SAHase
trypanomiasis
Online Access:http://www.mdpi.com/1420-3049/19/12/21200

Internet

http://www.mdpi.com/1420-3049/19/12/21200

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