The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease

The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease

Abstract Background Trimethylamine N-oxide (TMAO), a small molecule produced by the metaorganismal metabolism of dietary choline, has been implicated in human disease pathogenesis, including known risk factors for Alzheimer’s disease (AD), such as metabolic, cardiovascular, and cerebrovascular disea...

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Bibliographic Details
Main Authors: Nicholas M. Vogt, Kymberleigh A. Romano, Burcu F. Darst, Corinne D. Engelman, Sterling C. Johnson, Cynthia M. Carlsson, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Barbara B. Bendlin, Federico E. Rey
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Cerebrospinal fluid
Biomarkers
Trimethylamine N-oxide
Microbiota
Gut bacteria
Online Access:http://link.springer.com/article/10.1186/s13195-018-0451-2

Internet

http://link.springer.com/article/10.1186/s13195-018-0451-2

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