BL-7010 demonstrates specific binding to gliadin and reduces gluten-associated pathology in a chronic mouse model of gliadin sensitivity.

BL-7010 demonstrates specific binding to gliadin and reduces gluten-associated pathology in a chronic mouse model of gliadin sensitivity.

Celiac disease (CD) is an autoimmune disorder in individuals that carry DQ2 or DQ8 MHC class II haplotypes, triggered by the ingestion of gluten. There is no current treatment other than a gluten-free diet (GFD). We have previously shown that the BL-7010 copolymer poly(hydroxyethyl methacrylate-co-s...

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Bibliographic Details
Main Authors: Justin L McCarville, Yotam Nisemblat, Heather J Galipeau, Jennifer Jury, Rinat Tabakman, Ad Cohen, Esmira Naftali, Bela Neiman, Efrat Halbfinger, Joseph A Murray, Arivarasu N Anbazhagan, Pradeep K Dudeja, Alexander Varvak, Jean-Christophe Leroux, Elena F Verdu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4217726?pdf=render

Internet

http://europepmc.org/articles/PMC4217726?pdf=render

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