Temporal Stability of Lipid-Shelled Microbubbles During Acoustically-Mediated Blood-Brain Barrier Opening

Temporal Stability of Lipid-Shelled Microbubbles During Acoustically-Mediated Blood-Brain Barrier Opening

Non-invasive blood-brain barrier (BBB) opening using focused ultrasound (FUS) is being tested as a means to locally deliver drugs into the brain. Such FUS therapies require injection of pre-formed microbubbles, currently used as contrast agents in ultrasound imaging. Although their behavior during e...

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Bibliographic Details
Main Authors: Antonios N. Pouliopoulos, Daniella A. Jimenez, Alexander Frank, Alexander Robertson, Lin Zhang, Alina R. Kline-Schoder, Vividha Bhaskar, Mitra Harpale, Elizabeth Caso, Nicholas Papapanou, Rachel Anderson, Rachel Li, Elisa E. Konofagou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physics
Subjects:
focused ultrasound
microbubbles
temporal stability
contrast agents
passive cavitation detection
blood-brain barrier
Online Access:https://www.frontiersin.org/article/10.3389/fphy.2020.00137/full

Internet

https://www.frontiersin.org/article/10.3389/fphy.2020.00137/full

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