Fluid-electrolyte homeostasis requires histone deacetylase function

Fluid-electrolyte homeostasis requires histone deacetylase function

Histone deacetylase (HDAC) enzymes regulate transcription through epigenetic modification of chromatin structure, but their specific functions in the kidney remain elusive. We discovered that the human kidney expresses class I HDACs. Kidney medulla-specific inhibition of class I HDACs in the rat dur...

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Bibliographic Details
Main Authors: Kelly A. Hyndman, Joshua S. Speed, Luciano D. Mendoza, John M. Allan, Jackson Colson, Randee Sedaka, Chunhua Jin, Hyun Jun Jung, Samir El-Dahr, David M. Pollock, Jennifer S. Pollock
Format: Article
Language:English
Published: American Society for Clinical investigation 2020-08-01
Series:JCI Insight
Subjects:
Cell biology
Nephrology
Online Access:https://doi.org/10.1172/jci.insight.137792

Internet

https://doi.org/10.1172/jci.insight.137792

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