Evaluation of Immune Response against Leishmaniasis in BALB/c Mice Immunized with Cationic DOTAP/DOPE/CHOL Liposomes Containing Soluble Leishmania major Antigens

Evaluation of Immune Response against Leishmaniasis in BALB/c Mice Immunized with Cationic DOTAP/DOPE/CHOL Liposomes Containing Soluble Leishmania major Antigens

Background: Whole killed Leishmania vaccine reached phase III clinical trials but failed to display significant efficacy in human mainly due to limited Th1 inducer adjuvant. Liposomes consisting of 1, 2-dioleoyl-3trimethylammonium-propane (DOTAP) bearing an inherent adjuvanticity and 1, 2-dioleoyl-L...

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Bibliographic Details
Main Authors: Mansure HOJATIZADE, Ali BADIEE, Ali KHAMESIPOUR, Mahmoud Reza - JAAFARI
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2019-03-01
Series:Iranian Journal of Parasitology
Subjects:
L. major; BALB/c mice
Leishmania vaccine
Cationic liposomes
Dioleoyl-3trimethylammonium-propane
Online Access:http://ijpa.tums.ac.ir/index.php/ijpa/article/view/1534

Internet

http://ijpa.tums.ac.ir/index.php/ijpa/article/view/1534

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