The Peripheral Blood Transcriptome Is Correlated With PET Measures of Lung Inflammation During Successful Tuberculosis Treatment

The Peripheral Blood Transcriptome Is Correlated With PET Measures of Lung Inflammation During Successful Tuberculosis Treatment

Pulmonary tuberculosis (PTB) is characterized by lung granulomas, inflammation and tissue destruction. Here we used within-subject peripheral blood gene expression over time to correlate with the within-subject lung metabolic activity, as measured by positron emission tomography (PET) to identify bi...

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Bibliographic Details
Main Authors: Trust Odia, Stephanus T. Malherbe, Stuart Meier, Elizna Maasdorp, Léanie Kleynhans, Nelita du Plessis, Andre G. Loxton, Daniel E. Zak, Ethan Thompson, Fergal J. Duffy, Helena Kuivaniemi, Katharina Ronacher, Jill Winter, Gerhard Walzl, Gerard Tromp, the Catalysis TB-Biomarker Consortium, André G. Loxton, Annare Ellman, Bronwyn Smith, Caroline G. G. Beltran, Clifton E. Barry, David Alland, Friedrich Thienemann, James M. Warwick, Kim Stanley, Ilse Kant, Lani Thiart, Lance A. Lucas, Laura E. Via, Lori E. Dodd, Magdalena Kriel, Nelita Plessis Du, Patrick Dupont, Ray Y. Chen, Robert J. Wilkinson, Shubhada Shenai, Stephanie Griffith-Richards
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
gene expression
[18F]FDG PET-CT
RNA-sequencing
mixed-effect models
pathway analysis
transcription factor binding site
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.596173/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.596173/full

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